Based on a popular web manhua that famously uses simple stick-figure designs, Beryl and Sapphire is a unique anthology series that explores the infinite possibilities of human connection. The show does not follow a single linear plot; instead, it places its two protagonists—the calm, green-themed Beryl and the energetic, blue-themed Sapphire—into a different "world" or scenario in almost every episode.

The stories range from lighthearted, 8-minute comedy skits about office life and gaming to complex, multi-episode science fiction arcs and high-fantasy dramas. One of the most famous arcs, the "Demon King Arc," reimagines Beryl as a weary Demon Lord and Sapphire as the Knight sent to slay him, only for the two to form an unexpected bond. Other segments delve into deep psychological territory, exploring artificial intelligence, social media addiction, and the nature of love. Despite the varying settings and roles, the core theme remains the same: no matter the world or the circumstances, Beryl and Sapphire are destined to find each other.